Infectious diarrhea is a common disease in which doctors recommend taking an antibiotic called Vancomycin, but now there is hope that it can be effective in inflammatory bowel disease.
Antibiotic For Inflammatory Bowel Disease: According to a new study, an antibiotic used to treat infectious diarrhea may be an effective drug for a type of inflammatory bowel disease. Researchers at the University of Birmingham in the UK showed that an antibiotic called Vancomycin may also be effective in treating people who have a specific type of inflammatory bowel disease (IBD) that develops due to an incurable autoimmune liver disease called primary sclerosing cholangitis (PSC).
How was the research done?
It is noteworthy that 4 out of 5 patients who participated in this study achieved remission after taking the drug as part of a clinical trial published in the journal Crohn's and Colitis. The study is important because many participants with this disease did not respond to other IBD treatments.
Relationship between these 2 diseases
Furthermore, IBD and PSC are closely related, with most people with PSC developing IBD, and up to 14 percent of patients with IBD also developing PSC. Together, these conditions increase the risk of needing colon surgery and either developing colon or liver cancer, which will require a liver transplant. It also increases the overall risk of death.
What do the researchers say?
Dr. Mohammed Nabil Quraish of the University of Birmingham said, "Our findings suggest that vancomycin may offer a new therapeutic option for patients with this challenging combination of IBD and autoimmune liver disease."
During the trial, participants were treated with oral antibiotics for 4 weeks. Approximately 80 percent of patients achieved clinical remission. They also showed a significant reduction in inflammatory markers, and 100 percent showed mucosal healing. However, symptoms returned when treatment was discontinued after 8 weeks.
Vancomycin was also shown to induce changes in certain bile acids, which are now being further investigated to develop and refine treatments for IBD-associated PSC. The team said that although the results are preliminary, they provide a strong basis for further research.
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