IgG antibodies are commonly used in cancer treatment. They help the body's immune system fight cancer and are being considered as an alternative to chemotherapy and radiotherapy.
A scientific team is researching a new type of antibody that targets cancer cells by activating the body's immune system and may slow the growth of breast and ovarian cancer tumors that do not respond to treatment.
This antibody will cure cancer
An antibody called IgG is commonly used as immunotherapy for cancer treatment. It helps the body's immune system fight cancer and is being considered as an alternative to chemotherapy and radiotherapy. However, this treatment is not effective in some patients, especially in HER2-associated breast and ovarian cancers, and sometimes the body develops immunity to this treatment.
London scientists did research
To overcome this problem, scientists at King's College London researched a different type of antibody called IgE. This antibody activates the immune system in a different way than IgG. IgE antibodies awaken those immune cells of the body, which are usually not active and are present around the tumor. This directly targets cancer cells.
This thing came out in research
The researchers prepared and tested IgE antibodies instead of IgG antibodies. Dr. Heather Bax, a researcher at King's College London, said that IgE activated the immune system against cancer cells affected by HER2 and slowed down tumor growth in mice. This tumor was developed in mice that do not respond to traditional treatment. This indicates that this new technique can be beneficial for those patients on whom existing treatments do not work.
These cancer patients will benefit
Upon further study, scientists found that IgE antibodies can reactivate the immune system around the tumor. This increases the immune system's ability to fight cancer. This research has been published in the Journal for Immunotherapy of Cancer (JITC). According to Dr. Heather Bax, "A marker called HER2 is found in about 20% of breast and ovarian cancers. We prepared IgE antibodies against HER2 and found that it can activate the immune system in a new way. This can effectively target HER2 cancer cells, especially in cases where existing treatment does not work." She further said that this new discovery can become a new treatment option for patients suffering from HER2 cancer.
